A mini-review on Biginelli adducts with notable pharmacological properties

نویسندگان

  • Ângelo de Fátima
  • Taniris C. Braga
  • Leonardo da S. Neto
  • Bruna S. Terra
  • Breno G.F. Oliveira
  • Daniel L. da Silva
  • Luzia V. Modolo
چکیده

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2015